AustralieFrV1, Main, Exploration, bibRecord, 006612

The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?

Identifieur interne : 006612 ( Main/Exploration ); précédent : 006611; suivant : 006613

The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?

Auteurs : Arne Astrup [Danemark] ; J Rn Dyerberg [Danemark] ; Peter Elwood [Royaume-Uni] ; Kjeld Hermansen [Danemark] ; Frank B. Hu [États-Unis] ; Marianne Uhre Jakobsen [Danemark] ; Frans J. Kok [Pays-Bas] ; Ronald M. Krauss [États-Unis] ; Jean Michel Lecerf [France] ; Philippe Legrand [France] ; Paul Nestel [Australie] ; Ulf Riserus [Suède] ; Tom Sanders [Royaume-Uni] ; Andrew Sinclair [Australie] ; Steen Stender [Danemark] ; Tine Tholstrup [Danemark] ; Walter C. Willett [États-Unis]

Source :

The American journal of clinical nutrition [ 0002-9165 ] ; 2011.

RBID : Pascal:11-0197167

Descripteurs français

Pascal (Inist)
- Graisse saturée, Acide gras saturé, Prévention, Homme, Pathologie de l'appareil circulatoire.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Cardiovascular disease, Human, Prevention, Saturated fat, Saturated fatty acid.

Abstract

Current dietary recommendations advise reducing the intake of saturated fatty acids (SFAs) to reduce coronary heart disease (CHD) risk, but recent findings question the role of SFAs. This expert panel reviewed the evidence and reached the following conclusions: the evidence from epidemiologic, clinical, and mechanistic studies is consistent in finding that the risk of CHD is reduced when SFAs are replaced with polyunsaturated fatty acids (PUFAs). In populations who consume a Western diet, the replacement of 1 % of energy from SFAs with PUFAs lowers LDL cholesterol and is likely to produce a reduction in CHD incidence of >2-3%. No clear benefit of substituting carbohydrates for SFAs has been shown, although there might be a benefit if the carbohydrate is unrefined and has a low glycemic index. Insufficient evidence exists to judge the effect on CHD risk of replacing SFAs with MUFAs. No clear association between SFA intake relative to refined carbohydrates and the risk of insulin resistance and diabetes has been shown. The effect of diet on a single biomarker is insufficient evidence to assess CHD risk. The combination of multiple biomarkers and the use of clinical endpoints could help substantiate the effects on CHD. Furthermore, the effect of particular foods on CHD cannot be predicted solely by their content of total SFAs because individual SFAs may have different cardiovascular effects and major SFA food sources contain other constituents that could influence CHD risk. Research is needed to clarify the role of SFAs compared with specific forms of carbohydrates in CHD risk and to compare specific foods with appropriate altematives.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138219

Affiliations:

Le document en format XML

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<placeName><settlement type="city">Londres</settlement>
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<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sinclair, Andrew" sort="Sinclair, Andrew" uniqKey="Sinclair A" first="Andrew" last="Sinclair">Andrew Sinclair</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>School of Medicine, Deakin University</s1>
<s2>Victoria</s2>
<s3>AUS</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stender, Steen" sort="Stender, Steen" uniqKey="Stender S" first="Steen" last="Stender">Steen Stender</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Clinical/Biochemical Department, Gentofte Hospital, University of Copenhagen</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tholstrup, Tine" sort="Tholstrup, Tine" uniqKey="Tholstrup T" first="Tine" last="Tholstrup">Tine Tholstrup</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Willett, Walter C" sort="Willett, Walter C" uniqKey="Willett W" first="Walter C." last="Willett">Walter C. Willett</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Nutrition, Harvard School of Public Health</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The American journal of clinical nutrition</title>
<title level="j" type="abbreviated">Am. j. clin. nutr.</title>
<idno type="ISSN">0002-9165</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The American journal of clinical nutrition</title>
<title level="j" type="abbreviated">Am. j. clin. nutr.</title>
<idno type="ISSN">0002-9165</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiovascular disease</term>
<term>Human</term>
<term>Prevention</term>
<term>Saturated fat</term>
<term>Saturated fatty acid</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Graisse saturée</term>
<term>Acide gras saturé</term>
<term>Prévention</term>
<term>Homme</term>
<term>Pathologie de l'appareil circulatoire</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Current dietary recommendations advise reducing the intake of saturated fatty acids (SFAs) to reduce coronary heart disease (CHD) risk, but recent findings question the role of SFAs. This expert panel reviewed the evidence and reached the following conclusions: the evidence from epidemiologic, clinical, and mechanistic studies is consistent in finding that the risk of CHD is reduced when SFAs are replaced with polyunsaturated fatty acids (PUFAs). In populations who consume a Western diet, the replacement of 1 % of energy from SFAs with PUFAs lowers LDL cholesterol and is likely to produce a reduction in CHD incidence of >2-3%. No clear benefit of substituting carbohydrates for SFAs has been shown, although there might be a benefit if the carbohydrate is unrefined and has a low glycemic index. Insufficient evidence exists to judge the effect on CHD risk of replacing SFAs with MUFAs. No clear association between SFA intake relative to refined carbohydrates and the risk of insulin resistance and diabetes has been shown. The effect of diet on a single biomarker is insufficient evidence to assess CHD risk. The combination of multiple biomarkers and the use of clinical endpoints could help substantiate the effects on CHD. Furthermore, the effect of particular foods on CHD cannot be predicted solely by their content of total SFAs because individual SFAs may have different cardiovascular effects and major SFA food sources contain other constituents that could influence CHD risk. Research is needed to clarify the role of SFAs compared with specific forms of carbohydrates in CHD risk and to compare specific foods with appropriate altematives.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Danemark</li>
<li>France</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>East Middle Sweden</li>
<li>Grand Londres</li>
<li>Gueldre (province)</li>
<li>Hauts-de-France</li>
<li>Hovedstaden</li>
<li>Nord-Pas-de-Calais</li>
<li>Svealand</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Copenhague</li>
<li>Lille</li>
<li>Londres</li>
<li>Melbourne</li>
<li>Uppsala</li>
<li>Wageningue</li>
</settlement>
<orgName><li>Université d'Uppsala</li>
<li>Université de Wageningue</li>
</orgName>
</list>
<tree><country name="Danemark"><region name="Hovedstaden"><name sortKey="Astrup, Arne" sort="Astrup, Arne" uniqKey="Astrup A" first="Arne" last="Astrup">Arne Astrup</name>
</region>
<name sortKey="Dyerberg, J Rn" sort="Dyerberg, J Rn" uniqKey="Dyerberg J" first="J Rn" last="Dyerberg">J Rn Dyerberg</name>
<name sortKey="Hermansen, Kjeld" sort="Hermansen, Kjeld" uniqKey="Hermansen K" first="Kjeld" last="Hermansen">Kjeld Hermansen</name>
<name sortKey="Jakobsen, Marianne Uhre" sort="Jakobsen, Marianne Uhre" uniqKey="Jakobsen M" first="Marianne Uhre" last="Jakobsen">Marianne Uhre Jakobsen</name>
<name sortKey="Jakobsen, Marianne Uhre" sort="Jakobsen, Marianne Uhre" uniqKey="Jakobsen M" first="Marianne Uhre" last="Jakobsen">Marianne Uhre Jakobsen</name>
<name sortKey="Stender, Steen" sort="Stender, Steen" uniqKey="Stender S" first="Steen" last="Stender">Steen Stender</name>
<name sortKey="Tholstrup, Tine" sort="Tholstrup, Tine" uniqKey="Tholstrup T" first="Tine" last="Tholstrup">Tine Tholstrup</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Elwood, Peter" sort="Elwood, Peter" uniqKey="Elwood P" first="Peter" last="Elwood">Peter Elwood</name>
</noRegion>
<name sortKey="Sanders, Tom" sort="Sanders, Tom" uniqKey="Sanders T" first="Tom" last="Sanders">Tom Sanders</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name>
</noRegion>
<name sortKey="Krauss, Ronald M" sort="Krauss, Ronald M" uniqKey="Krauss R" first="Ronald M." last="Krauss">Ronald M. Krauss</name>
<name sortKey="Willett, Walter C" sort="Willett, Walter C" uniqKey="Willett W" first="Walter C." last="Willett">Walter C. Willett</name>
</country>
<country name="Pays-Bas"><region name="Gueldre (province)"><name sortKey="Kok, Frans J" sort="Kok, Frans J" uniqKey="Kok F" first="Frans J." last="Kok">Frans J. Kok</name>
</region>
</country>
<country name="France"><region name="Hauts-de-France"><name sortKey="Lecerf, Jean Michel" sort="Lecerf, Jean Michel" uniqKey="Lecerf J" first="Jean Michel" last="Lecerf">Jean Michel Lecerf</name>
</region>
<name sortKey="Legrand, Philippe" sort="Legrand, Philippe" uniqKey="Legrand P" first="Philippe" last="Legrand">Philippe Legrand</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Nestel, Paul" sort="Nestel, Paul" uniqKey="Nestel P" first="Paul" last="Nestel">Paul Nestel</name>
</region>
<name sortKey="Sinclair, Andrew" sort="Sinclair, Andrew" uniqKey="Sinclair A" first="Andrew" last="Sinclair">Andrew Sinclair</name>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Riserus, Ulf" sort="Riserus, Ulf" uniqKey="Riserus U" first="Ulf" last="Riserus">Ulf Riserus</name>
</region>
</country>
</tree>
</affiliations>
</record>

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The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?

The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?

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